Thank you for your interest in this study. This study is conducted by the Sleep and Chronobiology Laboratory at the University of Colorado at Boulder.
Biomarker of Peripheral Circadian Clocks in Humans
Healthy Men & Women Age 17-40
The purpose of this study is to improve our understanding of circadian rhythms in humans and specifically how light exposure and meal timing influences the levels of proteins that are measured in blood and saliva.
This study is 7 weeks long and involves 8 in-person lab visits to the Boulder campus (7 visits at the Sleep and Chronobiology Lab and 1 visit at the clinical translational research center [CTRC]). Visits range in duration from 15 minutes up to 7.7 days where you will live in the lab. During the two visits where you live in the lab, you will be studied in one of two conditions (bright light and meal timing) in a random order (e.g., the flip of a coin) as for which you complete first. Visit 1 will involve a consent process where you will learn more about the study and answer any questions you have. Visit 2 takes place at the CTRC and will involve a medical history and physical exam, and screening tests to evaluate your overall health. If you are eligible, based on the results of the procedures from the screening visits, we will ask you to wear a wrist worn research watch for 2 weeks at home and to complete a sleep diary. We will also ask you to wear for 3-days a sensor that will be placed on your upper arm to measure your blood sugar levels and to eat a 3-day research diet before the first and second in-lab visits. While living in the lab, on two occasions, you will not be aware of the time of day (e.g., no clocks, internet) and we will schedule your activities. We will frequently take blood and saliva samples for more than 24 hours and ask you to perform reaction time tests and tests of your ability to think and how you feel when you are asked to stay awake for up to 32 hours to measure proteins and hormones. We will also record your brain wave activity, muscle activity, eye movements and heart rate when you stay awake for up to 32 hours and during sleep opportunities. We will test you in one of the conditions (bright light or meal timing) in a simulated jet lag protocol during the in-lab visit. After the second occasion where you stay awake for up to 32 hours you will be permitted to have recovery sleep before being discharged from the lab. After one week where you are free to sleep when and as much as you want, we will repeat the 2 week at home monitoring with the wrist worn research watch and sleep diary. We will also repeat you wearing the sensor that placed on your upper arm to measure your blood sugar levels and eating a 3-day research diet before the second in-lab visit. Lastly, we will repeat the in-lab visit and you will be tested in the other condition (bright light or meal timing; opposite to what you were tested in first).
If you are eligible to participate in this study, you will be financially compensated for your involvement after the screening procedures. You will be compensated $75 for each week of home activity monitoring x 4 weeks, $220 for each 24h in the laboratory x 15.4 days, $40 for transportation to or from the laboratory visits x 4 times, and an additional $245 as a study completion bonus. The total compensation can be up to $4,093
If you are interested in applying to participate in this study, please complete this online application survey that helps to see if you are likely to qualify to be in the study. In order to do this, we will ask you some eligibility questions, which will include questions about your medical history, sleep habits, medication and drug use. It should take about 10-15 minutes to go through these questions. Some of the questions may make you uncomfortable; you do not have to answer any question that you would not like to answer, but without answers to these questions, you will not be eligible to participate in the study. If you do not enroll in this study, we will keep the information during this pre-screening. We are also required to give you the number of University of Colorado - Boulder IRB, the Ethics Board that oversees our research: it is (303) 735-3702, in case you have any questions or concerns for them.
We will contact you within one week to let you know if you qualify for the first consent screening appointment. If you need assistance with this survey, have additional questions about the study, or would like to complete the survey via the telephone, please contact us at (303) 735-1923 (M-F, 9am-5pm). With the email address of sleep.study@colorado.edu , general questions can also be answered.
Checking "I agree" documents that you have read the information about the study and give your permission to take part in the initial screening for this research.
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What is your name?
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What is your assigned sex?
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What is your address?
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How old are you?
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What is your date of birth (MM-DD-YYYY)?
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Today M-D-Y
What is your current occupation?
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On average, how many hours per week do you work?
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What month(s) would you be available to spend 7.7 days on two occasions 21 days apart in the laboratory for the study?
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Have you ever participated in a research study?
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What type of research study did you participate in?
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When did you last participate in a research study, if current please indicate current?
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Did the research study involve blood draws? If so, how much blood did you donate?
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Did the research study involve taking medication? If so, please list the name of the medication.
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How tall are you (feet, inches)?
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How much do you weigh (in pounds)?
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How long have you weighed this much?
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What is the most that you have weighed in your lifetime, excluding pregnancy (in pounds)?
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Do you exercise regularly?
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How often do you exercise?
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What type of exercise do you do?
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Which is your dominant hand?
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Both
Have you ever been diagnosed with a medical problem or illness?
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What medical problem(s) or illness(es) have you been diagnosed with, and when did this occur?
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Have you ever been diagnosed with a psychological or psychiatric problem or illness?
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What psychological or psychiatric problem(s) or illness(es) have you been diagnosed with, and when did this occur?
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Do you use any prescription medication?
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Please provide the name of the medication(s), dose, length of use, and the reason you are using it.
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Do you use hormones (e.g. contraceptive birth control), inhalers, or medicated patches (e.g. birth control, nicotine)?
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Please provide the name of the hormone, inhaler, or patch, the dose, how long you have been using it, and for what purpose.
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Next is a series of questions about your medical history. Please indicate if you have now or have ever had any of the following conditions. If your response is "Yes" to a question, please explain when the problem was identified or diagnosed, what treatment you use(d) for it and when, and whether you experienced any complications from it.
Have you ever had or do you currently have heart disease or a heart murmur?
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What heart disease(s) or murmurs have you had? When were they identified? If they are treated, how? Have you had any complications from this?
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Have you ever had or do you currently have any type of lung disease?
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What lung disease(s) have you had? When were they identified? If they are treated, how? Have you had any complications from this?
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Have you ever had or do you currently have any type of kidney disease?
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What kidney disease(s) have you had? When were they identified? If they are treated, how? Have you had any complications from this?
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Have you ever had any type of stomach or intestine disease [e.g. ulcers, acid reflux, Irritable Bowel Syndrome (IBS), disordered gag reflex, previous stomach/intestine surgery, ridging (felinization) of the tube (i.e., the esophagus) that connects your throat to your stomach, slower transit (e.g., hypomotility) disorders of the stomach/intestine]?
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What stomach disease have you had? When were they identified? If they are treated, how? Have you had any complications from this?
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Do you have any implanted electromedical devices?
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Have you ever had and do you currently have any type of visual impairment?
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What type of visual impairment did you have or do you currently have?
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Do you wear contact lenses or glasses?
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What type of corrective lenses do you use?
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Primarily contact lenses Primarily eyeglasses Both contact lenses and eyeglasses
Have you had any eye injuries?
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What type of eye injury have you had? When did this occur? If it was treated, how? Have you had any complications from this?
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Are you colorblind?
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What type of colorblindness do you have?
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Do you have any hearing impairments?
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What type of hearing impairment do you have?
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Have you ever had any type of neurological disease (e.g. stroke, seizures, migraine headaches)?
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What type of neurological disease have you had? When was it identified? If it is treated, how? Have you had any complications from this?
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Have you ever been diagnosed with peripheral neuropathy associated with cold intolerance, numbness and skin color changes in the hands, complex regional pain syndrome (CRPS), Raynaud phenomenon, occlusive vascular disease of the hand, acrocyanosis, erythromelalgia, or metabolic or autoimmune diseases that affect digital blood flow?
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If so, please explain:
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Have you experienced accidents, head injuries, concussions, or loss of consciousness?
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What was the nature of your accident, head injury, or concussion? What length of time did you lose consciousness for, if at all? When did the incident occur, what (if any) treatment have you undergone for it, and have you experienced any long term complications because of it?
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Have you ever had or do you currently have thyroid disease (e.g. hyper or hypothyroidism)?
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What type of thyroid disease have you had? When was it identified? If it is treated, how?
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Have you had or do you have high blood pressure?
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If so, please explain:
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Do you have diabetes?
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Do you have hepatitis?
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What type of hepatitis do you have?
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Have you ever had or do you now have asthma?
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Has your asthma been influenced by age, physical activity, or temperature? How do you manage or treat it?
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Have you ever had surgery?
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What type of surgery? When? Was local or general anesthesia used? Did you have any complications following the surgery?
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What type of caffeine do you typically consume? (Check all that apply)
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How much caffeinated coffee do you drink and how often? Please specify the size of the drink (e.g. 8 oz., or Starbucks Grande size), and the number you consume per day, week, or month.
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How much caffeinated tea do you drink and how often? Please specify the size of the drink (e.g. 8 oz., or 1 mug) and the number you consume per day, week, or month.
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How many caffeinated soft drinks do you consume, and how often? Please specify the size of the drink (e.g. one 12 ounce can or one 20 ounce bottle) and how many you consume per day, week, or month.
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How much chocolate do you eat and how often?
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Please specify the energy drink you use, the size, and how many you consume per day, week, or month.
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Please indicate if you use the following: (check all that apply)
What type of sedatives do you use, what dose, how often, and for what purpose?
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What antihistamines do you use, what dose, how frequently, and for what purpose?
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What type of pain reliever do you use, what dose, how frequently, and for what purpose?
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What type of antacid do you use, how frequently, and for what purpose?
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Do you drink alcohol?
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On average, how many days per week do you drink alcohol, and how much do you drink on each occasion?
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Do you ever use tobacco?
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What type of tobacco do you use? (check all that apply)
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How long have you chewed tobacco, how much, and how often do you chew?
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How long have you smoked cigarettes, how many cigarettes do you smoke per day?
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How long have you smoked cigars, pipe tobacco, or hookah and how much do you smoke per day?
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Do you currently use marijuana?
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How long have you used marijuana, how much, and how often?
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Do you have any problems with your sleep?
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What type of problems do you have with your sleep?
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How long does it usually take you to fall asleep?
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How many hours do you sleep in an average night?
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What is your usual bedtime on weekdays?
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What is your usual wake time on weekdays?
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What is your usual bedtime on weekends?
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What is your usual wake time on weekends?
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Are you a caregiver for a dependent requiring frequent nighttime care/sleep interruptions?
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Yes
No
Have you traveled outside the mountain time zone within the past 3 months?
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Yes
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Where did you go and what date did you return?
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Do you have future travel plans that may conflict with participation in this study; if so, when and to where?
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Have you ever worked the night shift?
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Yes
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What hours did you work on the night shift?
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How many days per week did you work the night shift?
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How long (months or years) did you work night shifts?
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What month and year did you stop doing night shift work?
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As of today, how long have you lived at the altitude of Denver or higher?
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Have you spent time away from home and your family (e.g., summer camp)?
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Yes
No
When was the last time your spent time away from home?
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How long were you away?
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How did it go?
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Did you get home sick?
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How did you hear about this research study?
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Do you use hormonal contraceptives?
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Yes
No
What type of hormonal contraceptive do you use?
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How long have you been using this hormonal contraceptive?
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How many days are there from the start of one menstrual period to the start of the next menstrual period for you?
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What was the start date of your last menstrual cycle?
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Today M-D-Y
What was the start date of your menstrual cycle prior to that? (e.g. your second-to-last menstrual cycle)
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Today M-D-Y
Is the number of days between your menstrual period consistent from month to month?
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Yes
No
Please explain how the length of time between your menstrual periods varies from month to month.
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Have you given birth in the past year?
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Yes
No
Are you currently breastfeeding?
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Yes
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Please check all of the following dietary descriptions that apply to you:
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Do you give permission for us to leave detailed voice messages and emails at the phone number and email provided?
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I give my permission for my information to be included in the study doctors recruitment database to take part in other current studies I may qualify for, or for future research.
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Initials
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If I answered yes, I understand that I may later change my mind, and that I can contact the Sleep and Chronobiology Staff in writing to have my contact information destroyed.