Thank you for your interest in this study. This study is conducted by the Sleep and Chronobiology Laboratory at the University of Colorado Boulder.
Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder (DSWPD) Study
Males and Females Age 16-30 People with a diagnosis of delayed-sleep wake phase disorder People with late bedtimes, an inability to fall asleep, and difficulty waking when required for school/work Healthy people with typical bedtimes and no sleep concerns Purpose of Study The purpose of the study is to understand mechanisms of DSWPD. This study will improve our understanding of circadian rhythms in humans and may help us to create treatments and strategies for DSWPD. Study Visits & Compensation This study is ~6.5 weeks long and involves 6 in-person lab visits to the University of Colorado Boulder campus (up to 5 visits at the Sleep and Chronobiology Laboratory and 1 visit at the Clinical Translational Research Center). If you qualify for the study and choose to participate, there will be two visits where you will pick up research equipment to wear at home for 1-2 weeks of ambulatory monitoring before being studied in the laboratory. The first ambulatory monitoring session is for 2 weeks and the second is for one week. On the first ambulatory monitoring session we will have you answer questions about your mood and cognition and we will also ask you to wear a blood sugar monitor and track the timing of when you eat using a phone app On both ambulatory monitoring sessions we will have you wear a wrist-worn sleep and light monitor plus a daily sleep log and online form of when you go to bed and wake up. Next there will be a visit where you will spend ~66 hours (~2.75 days) in the laboratory While living in the lab, you will not be aware of the time of day (e.g., no clocks, internet, cell phones), and we will schedule your activities. We will ask you to remain seated in bed and awake for up to 40 hours, with the head of the bed raised. You will be studied under dim light similar to candlelight. We will frequently take saliva samples for more than 24 hours when we will ask you to stay awake for up to 40 hours. We will also take four blood samples. We will also ask you to perform reaction time tests, tests of your ability to think, and to complete ratings of how you feel multiple times each day that you are in the lab. We will also record your brain wave activity, muscle activity, eye movements, and heart rate when you stay awake for up to 40 hours and during sleep opportunities. We will then ask you to sleep normally at home for ~2 weeks, followed by 1 week of ambulatory monitoring. Finally, there will be a visit where you will spend ~48 hours (~2 days) in the laboratory) While living in the lab, you will not be aware of the time of day (e.g., no clocks, internet, cell phones) and we will schedule your activities. We will expose you to different light levels (dim light similar to candlelight and typical room light). We will frequently take saliva samples. We will also ask you to perform reaction time tests, tests of your ability to think and to complete ratings of how you feel multiple times each day that you are in the lab. We will also record your brain wave activity, muscle activity, eye movements, and heart rate when you are awake and while you sleep. If you are eligible to participate in this study, you will be financially compensated for your involvement after the screening procedures. You will be compensated $100 for each week of home activity monitoring x 3 weeks, $200 for each 24h in the laboratory x 4.75 days, $80 for transportation when you live in the laboratory (3 visits), and an additional $275 as a study completion bonus. The total compensation can be up to $1,765. Survey Instructions If you are interested in applying to participate in this study, please complete this online application survey that helps to see if you are likely to qualify to be in the study. In order to do this, we will ask you some eligibility questions, which will include questions about your medical history, sleep habits, medication and drug use. It should take about 10-15 minutes to go through these questions. Some of the questions may make you uncomfortable; you do not have to answer any question that you would not like to answer, but without answers to these questions, you will not be eligible to participate in the study. If you do not enroll in this study, we will keep the information during this pre-screening. We are also required to give you the number of the University of Colorado Boulder IRB, the Ethics Board that oversees our research: it is (303)735-3702, in case you have any questions or concerns for them. We will contact you within one week to let you know if you qualify for the first consent screening appointment. If you need assistance with this survey, have additional questions about the study, or would like to complete the survey via the telephone, please contact us at (303) 735-1923 (M-F, 9am-5pm). With the email address of sleep@colorado.edu, general questions can also be answered. Checking "I agree" documents that you have read the information about the study and give your permission to take part in the initial screening for this research.
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I agree
I do not agree
What is your name?
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First and Last Name; e.g. Rachel Smith
Female
Male
What is your address?
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Please include street address, zipcode, city, and state
What is your phone number?
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What is your email address?
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How old are you?
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What is your date of birth?
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M-D-Y
Unfortunately, you are not eligible to participate in this study. Thank you for your time and interest! What is your current occupation?
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On average, how many hours per week do you work?
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What month(s) would you be available to participate in the study?
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Have you ever participated in a research study?
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Yes
No
What type of research study did you participate in?
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When did you last participate in a research study? If current, please indicate current.
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Did the research study involve blood draws? If so, how much blood did you donate?
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Did the research study involve taking medication? If so, please list the name of the medication.
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How tall are you (feet, inches)?
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How much do you weigh (in pounds)?
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How long have you weighed this much?
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What is the most that you have weighed in your lifetime, excluding pregnancy (in pounds)?
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On average, what time do you eat your first meal, beverage, or snack? This is the absolute first thing you consume with any calories
What do you usually eat for your first meal or snack of the day?
On average, what time do you eat your second meal of the day?
What do you usually consume for your second meal or lunch?
On average, what time do you eat your last meal, beverage, or snack? This is the absolute last thing you consume with calories.
What do you usually consume for your last meal or snack of the day?
Do you exercise regularly?
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Yes
No
How often do you exercise?
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What type of exercise do you do?
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Which is your dominant hand?
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Right
Left
Both
Have you ever been diagnosed with a medical problem or illness?
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Yes
No
What medical problem(s) or illness(es) have you been diagnosed with, and when did this occur?
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Have you ever been diagnosed with a psychological or psychiatric problem or illness?
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Yes
No
What psychological or psychiatric problem(s) or illness(es) have you been diagnosed with, and when did this occur?
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Do you use any prescription medication?
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Yes
No
Please provide the name of the medication(s), dose, length of use, and the reason you are using it.
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e.g. Adderall, 20 mg daily, for 3 years, ADHD
Do you use hormones (e.g. contraceptive birth control), inhalers, or medicated patches (e.g. birth control, nicotine)?
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Yes
No
Please provide the name of the hormone, inhaler, or patch, the dose, how long you have been using it, and for what purpose.
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e.g. Albuterol inhaler, 1 puff as needed, 6 years, asthma
Do you use any supplements/vitamins/over the counter medications?
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Yes
No
Please provide the name of the supplement(s), dose, length of use, and the reason you are using it.
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e.g. Vitamin D3, 125 mcg daily, 2 months, Dr recommended it during the winter
Are any of the supplements/vitamins/over the counter medications used prescribed by a physician?
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Next is a series of questions about your medical history. Please indicate if you have now or have ever had any of the following conditions. If your response is "Yes" to a question, please explain when the problem was identified or diagnosed, what treatment you use(d) for it and when, and whether you experienced any complications from it. Have you ever had heart disease or a heart murmur?
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Yes
No
What heart disease(s) or murmurs have you had? When were they identified? If they are treated, how? Have you had any complications from this?
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Have you been diagnosed with deep vein thrombosis or other blood clotting disorders?
Yes
No
What blood clotting disorder(s) have you had?
Have you ever had or do you currently have any type of lung disease?
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Yes
No
What lung disease(s) have you had? When were they identified? If they are treated, how? Have you had any complications from this?
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Have you ever had or do you currently have any type of kidney disease?
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Yes
No
What kidney disease(s) have you had? When were they identified? If they are treated, how? Have you had any complications from this?
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Have you ever had any type of stomach or intestine disease [e.g. ulcers, acid reflux, Irritable Bowel Syndrome (IBS), disordered gag reflex, previous stomach/intestine surgery, ridging (felinization) of the tube (i.e., the esophagus) that connects your throat to your stomach, slower transit (e.g., hypomotility) disorders of the stomach/intestine]?
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Yes
No
What stomach disease have you had? When were they identified? If they are treated, how? Have you had any complications from this?
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Do you have any implanted electromedical devices?
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Yes
No
What implanted electromedical devices do you have?
Have you ever had and do you currently have any type of visual impairment?
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Yes
No
What type of visual impairment do you have?
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Do you wear contact lenses or glasses?
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Yes
No
What type of corrective lenses do you use?
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Primarily contact lenses
Primarily eyeglasses
Both contact lenses and eyeglasses
Have you had any eye injuries?
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Yes
No
What type of eye injury have you had? When did this occur? If it was treated, how? Have you had any complications from this?
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Are you colorblind?
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No
Yes
I don't know
What type of colorblindness do you have?
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Do you have any hearing impairment?
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Yes
No
What type of hearing impairment do you have?
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Have you ever had any type of neurological disease (e.g. stroke, seizures, migraine headaches)?
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Yes
No
What type of neurological disease have you had? When was it identified? If it is treated, how? Have you had any complications from this?
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Have you ever been diagnosed with peripheral neuropathy associated with cold intolerance, numbness and skin color changes in the hands, complex regional pain syndrome (CRPS), Raynaud phenomenon, occlusive vascular disease of the hand, acrocyanosis, erythromelalgia, or metabolic or autoimmune diseases that affect digital blood flow?
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Yes
No
What peripheral neuropathy do you have?
Have you experienced accidents, head injuries, concussions, or loss of consciousness?
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Yes
No
What was the nature of your accident, head injury, or concussion? What length of time did you lose consciousness for, if at all? When did the incident occur, what (if any) treatment have you undergone for it, and have you experienced any long term complications because of it?
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Have you ever had or do you currently have thyroid disease (e.g. hyper or hypothyroidism)?
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Yes
No
What type of thyroid disease have you had? When was it identified? If it is treated, how?
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Have you had or do you have high blood pressure?
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Yes
No
When did you have high blood pressure? Was it treated, and how?
Do you have diabetes?
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Yes
No
Do you have hepatitis?
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No
Yes
I don't know
What type of hepatitis do you have?
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Have you ever had or do you now have asthma?
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Yes
No
Has your asthma been influenced by age, physical activity, or temperature? How do you manage or treat it?
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Have you ever had surgery?
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Yes
No
What type of surgery? When? Was local or general anesthesia used? Did you have any complications following the surgery?
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What type of caffeine do you typically consume?
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How much coffee do you drink and how often? Please specify the size of the drink (e.g. 8 oz., or, Starbucks Grande size), and the number you consume per day, week, or month.
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How much caffeinated tea do you drink and how often? Please specify the size of the drink (e.g. 8 oz. or 1 mug) and the number you consume per day, week, or month.
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How many caffeinated soft drinks do you consume, and how often? Please specify the size of the drink (e.g. one 12 ounce can or one 20 ounce bottle) and how many you consume per day, week, or month.
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Please specify the energy drink you use, the size, and how many you consume per day, week, or month.
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How much chocolate do you eat and how often?
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Please indicate if you use the following: (check all that apply)
What type of sedatives do you use, what dose, how often, and for what purpose?
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What antihistamines do you use, what dose, how frequently, and for what purpose?
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What type of pain reliever do you use, what dose, how frequently, and for what purpose?
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What type of antacid do you use, and how frequently, and for what purpose?
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Do you drink alcohol?
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Yes
No
On average, how many days per week or per month do you drink alcohol, and how much do you drink on each occasion?
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Do you ever use tobacco?
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Yes
No
What type of tobacco do you use? (check all that apply)
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How long have you chewed tobacco, and how often do you chew?
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How long have you smoked cigarettes, and how many cigarettes do you smoke per day?
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How long have you smoked cigars, pipe tobacco, or hookah and how much do you smoke per day?
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Do you currently use marijuana?
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Yes
No
How long have you used marijuana, how much, and how often?
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Do you have any problems with your sleep?
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Yes
No
What type of problems do you have with your sleep?
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How long does it usually take you to fall asleep?
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How many hours do you sleep in an average night?
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What is your usual bedtime on weekdays?
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Now H:M
What is your usual wake time on weekdays?
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Now H:M
What is your usual bed time on weekends?
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Now H:M
What is your usual wake time on weekends?
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Now H:M
How many naps do you take per week?
How long do you usually nap?
Are you a caregiver for a dependent requiring frequent nighttime care/sleep interruptions?
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Yes
No
Do you have a diagnosis of delayed-sleep wake phase disorder?
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Yes
No
Have you traveled outside the mountain time zone within the past 3 months?
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Yes
No
Where did you go and what date did you return?
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Do you have future travel plans that may conflict with participation in this study; if so, when and to where?
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Have you ever worked the night shift?
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Yes
No
What hours did you work on the night shift?
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How many days per week did you work the night shift?
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How long (months or years) did you work night shifts?
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What month and year did you stop doing night shift work?
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As of today, how long have you lived at the altitude of Denver or higher?
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Have you spent time away from home and your family (e.g., summer camp)
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Yes
No
When was the last time you spent time away from home?
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How long were you away?
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How did it go?
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Did you get home sick?
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Yes
No
How did you hear about this research study?
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Other:
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Do you use hormonal contraceptives?
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Yes
No
What type of hormonal contraceptive do you use?
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How long have you been using this hormonal contraceptive?
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How many days are there from the start of one menstrual period to the start of the next menstrual period for you?
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What was the start date of your last menstrual cycle?
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Today M-D-Y
What was the start date of your menstrual cycle prior to that? (i.e. your second-to-last menstrual cycle)
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Today M-D-Y
Is the number of days between your menstrual period consistent from month to month?
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Yes
No
Please explain how the length of time between your menstrual periods varies from month to month.
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Have you given birth in the past year?
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Yes
No
Are you currently breastfeeding?
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Yes
No
Please check all of the following dietary descriptions that apply to you:
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Do you give permission for us to leave detailed voice messages and emails at the phone number and email provided?
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Yes
No
I give my permission for my information to be included in the study doctor's recruitment database to take part in other current studies I may qualify for, or for future research.
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Yes
No
Initials
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If I answered yes, I understand that I may later change my mind, and that I can contact the Sleep and Chronobiology Staff in writing to have my contact information destroyed.